Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:6853107 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
685310768544291323probable sugar transport system sugar-binding lipoprotein SC2H413cQuickGO ontologyBLASTP
685470168571632463beta-mannosidaseQuickGO ontologyBLASTP
685716068581881029transcriptional regulatorQuickGO ontologyBLASTP
685844068595941155secreted beta-mannosidaseQuickGO ontologyBLASTP
68596586859903246hypothetical proteinBLASTP
68599006860775876DNA-binding proteinQuickGO ontologyBLASTP
68608826861364483regulatory proteinQuickGO ontologyBLASTP
68614176862082666hypothetical proteinBLASTP
68623076863275969sigma factorQuickGO ontologyBLASTP
68633586864092735hypothetical proteinBLASTP
68643266864658333hypothetical proteinBLASTP
68647556865669915hypothetical proteinBLASTP
686573668673581623malate synthaseQuickGO ontologyBLASTP
68675436868166624hypothetical proteinBLASTP
68683206868634315hypothetical protein
68686576869469813transcriptional regulator for glyoxylate bypassQuickGO ontologyBLASTP
686972568710621338allantoinaseQuickGO ontologyBLASTP
687112768722571131allantoicaseQuickGO ontologyBLASTP
687232968731057773-oxoacyl-acyl-carrier-protein reductaseQuickGO ontologyBLASTP