Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:6233478 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
623347862367293252hypothetical proteinBLASTP
623720862387821575secreted proteinQuickGO ontologyBLASTP
62388206239620801hypothetical proteinBLASTP
623961762408851269hypothetical proteinBLASTP
624107062425961527hypothetical proteinBLASTP
624266862439091242serine protease secreted proteinQuickGO ontologyBLASTP
62439386244234297regulator BldBQuickGO ontologyBLASTP
62445386244912375hypothetical protein
62449496245260312hypothetical protein
62453816245860480hypothetical protein
62458846246486603hypothetical proteinBLASTP
62465176247155639secreted proteinQuickGO ontology
624718462494212238hypothetical proteinBLASTP
62494236249845423hypothetical proteinBLASTP
624991162512631353secreted serine proteaseQuickGO ontologyBLASTP
625129462528471554hypothetical proteinBLASTP
62528476253335489hypothetical proteinBLASTP