Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:5550582 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
55505825551418837integral membrane proteinQuickGO ontologyBLASTP
55514805551920441hypothetical proteinBLASTP
555209355544082316lipoproteinQuickGO ontologyBLASTP
555454155564481908GTP-binding proteinQuickGO ontologyBLASTP
555735555583861032BldKA ABC transport system integral membrane proteinQuickGO ontologyBLASTP
555849855603001803BldKB ABC transport system lipoproteinQuickGO ontologyBLASTP
55604145561391978BldKC ABC transport system integral membrane proteinQuickGO ontologyBLASTP
556140255624631062BldKD ABC transporter intracellular ATPase subunitQuickGO ontologyBLASTP
556249155636361146peptide transport system ATP-binding subunitQuickGO ontologyBLASTP
556383655654701635peptide transport system secreted peptide-binding proteinQuickGO ontologyBLASTP
55654805566403924peptide transport system integral membrane proteinQuickGO ontologyBLASTP
55664595567376918peptide transport system integral membrane proteinQuickGO ontologyBLASTP
55673855568368984peptide transport system ATP-binding proteinQuickGO ontologyBLASTP
556836155694311071peptide transport system ATP-binding proteinQuickGO ontologyBLASTP
556956455716872124peptidaseQuickGO ontologyBLASTP