Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:4927170 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
492717049289301761serinethreonine protein kinaseQuickGO ontologyBLASTP
492899149335684578cell division-related proteinQuickGO ontologyBLASTP
49337824934156375hypothetical proteinBLASTP
49341904934597408hypothetical protein
49346884935107420integral membrane proteinQuickGO ontology
49351044935685582hypothetical proteinBLASTP
49356824936350669hypothetical protein
49363474936925579integral membrane proteinQuickGO ontology
493695949381641206hypothetical proteinBLASTP
49381614938520360hypothetical proteinBLASTP
49387904939515726hypothetical protein
493951249408611350integral membrane proteinQuickGO ontology
49409664941562597integral membrane proteinQuickGO ontology
49415674941872306hypothetical protein
494189549429801086secreted proteinQuickGO ontologyBLASTP
49429774943453477hypothetical protein
49437034944296594integral membrane proteinQuickGO ontology
49451264945845720hypothetical protein
49458644946745882hypothetical protein
494674249480491308protein kinaseQuickGO ontologyBLASTP
494806349491001038integral membrane proteinQuickGO ontologyBLASTP
49491094950017909integral membrane proteinQuickGO ontologyBLASTP
49500144950367354integral membrane proteinQuickGO ontology
49503954950955561hypothetical protein
49509564951393438septum determining proteinQuickGO ontologyBLASTP
49513904951851462hypothetical protein
49519304952256327hypothetical proteinBLASTP
495225349536771425hypothetical proteinBLASTP
495367449550021329integral membrane proteinQuickGO ontology
49549994955643645hypothetical proteinBLASTP
49556404956245606hypothetical protein 2SCD408QuickGO ontology
49563014956636336hypothetical protein 2SCD409cQuickGO ontologyBLASTP
49566594957264606hypothetical proteinBLASTP
49573024957544243hypothetical protein 2SCD411cQuickGO ontologyBLASTP
495772349593031581hypothetical proteinBLASTP
49593824959573192hypothetical proteinBLASTP
49595844960435852hypothetical proteinBLASTP
49606494961074426hypothetical proteinBLASTP
49611084962022915hypothetical proteinBLASTP
49621284962778651lipoproteinQuickGO ontologyBLASTP
496277849638451068secreted proteinQuickGO ontologyBLASTP
496406149670693009integral membrane proteinQuickGO ontologyBLASTP
49670664967845780type IV peptidaseQuickGO ontologyBLASTP
496792449691231200hypothetical proteinBLASTP
49691314969730600hypothetical protein
496976649707701005hydrolaseQuickGO ontologyBLASTP
49709644971383420hypothetical protein
497140149736322232bi-functional transferasedeacetylaseQuickGO ontologyBLASTP
497363249747231092integral membrane transferaseQuickGO ontology