Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:4750489 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
47504894750677189hypothetical protein
47508284751265438marR-family proteinQuickGO ontologyBLASTP
475129347526721380integral membrane efflux proteinQuickGO ontologyBLASTP
47527224753294573hypothetical protein
47534364754290855reductaseQuickGO ontologyBLASTP
475436647560151650integraseQuickGO ontologyBLASTP
47561504756464315hypothetical protein
47568614757403543hypothetical proteinBLASTP
47574364757633198hypothetical proteinBLASTP
47577154758560846transposaseQuickGO ontologyBLASTP
47590424759623582hypothetical protein
475989147610001110hypothetical proteinBLASTP
47612454761673429hypothetical proteinBLASTP
476167047638412172hypothetical proteinBLASTP
476383847655531716hypothetical proteinBLASTP
476555347669051353integraseQuickGO ontologyBLASTP
47671154767627513DNA invertaseQuickGO ontologyBLASTP
47676844768676993oxidoreductaseQuickGO ontologyBLASTP
47688144768972159hypothetical proteinBLASTP
47690204769703684hypothetical protein
47697044770477774nucleotidyltransferaseQuickGO ontologyBLASTP
47704504771139690hypothetical protein
477119547722411047integral membrane proteinQuickGO ontologyBLASTP
47722154773021807tetR family transcriptional regulatory proteinQuickGO ontologyBLASTP
477311847741281011ABC transport system ATP-binding proteinQuickGO ontologyBLASTP
47741254774967843ABC transport system integral membrane proteinQuickGO ontologyBLASTP