Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:4613000 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
461313646146261491glycosyltransferaseQuickGO ontologyBLASTP
46146194615125507hypothetical proteinBLASTP
46151544615969816AraC-family transcriptional regulatorQuickGO ontologyBLASTP
46160194616486468hypothetical proteinBLASTP
461656946178581290integral membrane transport proteinQuickGO ontologyBLASTP
46180204618781762phosphoglyceromutaseQuickGO ontologyBLASTP
46188814619375495hypothetical proteinBLASTP
46194324620040609integrase partial CDSQuickGO ontologyBLASTP
46203054620667363hypothetical protein
462109146227251635hypothetical proteinBLASTP
46229934623433441AbaA-like regulatory proteinQuickGO ontologyBLASTP
46237664624524759GntR-family regulatory proteinQuickGO ontologyBLASTP
46245874624796210hypothetical protein
46249324625816885hypothetical proteinBLASTP
46259754626166192small hydrophilic proteinQuickGO ontology
46263944627158765hydrolase dienelactone hydrolase familyQuickGO ontologyBLASTP
46273484627767420hypothetical proteinBLASTP
46278324628248417hypothetical proteinBLASTP
46283574628737381hypothetical proteinBLASTP
46287654629652888AraC-family transcriptional regulatorQuickGO ontologyBLASTP
462972446309891266hypothetical proteinBLASTP
46310734631465393integral membrane proteinQuickGO ontology