Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:4523500 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45235024524395894tetR-family transcriptional regulatorQuickGO ontologyBLASTP
452482145261491329NADH dehydrogenaseQuickGO ontologyBLASTP
452633245279901659hypothetical proteinBLASTP
452804545293221278integral membrane proteinQuickGO ontologyBLASTP
45294684530016549MarR-family transcriptional regulatorQuickGO ontologyBLASTP
45358624536530669two-component system response regulatorQuickGO ontologyBLASTP
453652745378971371two-component sensor kinaseQuickGO ontologyBLASTP
45379234538456534acetyltransferaseQuickGO ontologyBLASTP
453850445399911488hypothetical proteinBLASTP
454006545414801416ATPGTP-binding proteinQuickGO ontologyBLASTP
454149345430341542hypothetical proteinBLASTP
454304945443111263integral membrane proteinQuickGO ontologyBLASTP
45443704545170801integral membrane proteinQuickGO ontologyBLASTP
45453384545646309integral membrane proteinQuickGO ontologyBLASTP
454602945470511023secreted transglycosylaseQuickGO ontologyBLASTP
45472574547973717integral membrane proteinQuickGO ontologyBLASTP
454797745495601584lipoproteinQuickGO ontologyBLASTP