Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:4377000 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
43775054378143639regulatorQuickGO ontologyBLASTP
43782714379098828phosphodiesteraseQuickGO ontologyBLASTP
437936443809231560protease secreted proteinQuickGO ontologyBLASTP
43810654381949885oxidoreductaseQuickGO ontologyBLASTP
43820304382620591TetR-family transcriptional regulatorQuickGO ontologyBLASTP
4382684438276885tRNA-SerQuickGO ontologyBLASTP
43828984383473576hypothetical protein
43836164384371756GntR-family transcriptional regulatorQuickGO ontologyBLASTP
43844514384729279hypothetical proteinBLASTP
43847424385053312hypothetical proteinBLASTP
43850534385256204hypothetical proteinBLASTP
43852534385477225hypothetical proteinBLASTP
43854864386217732GntR-family transcriptional regulatorQuickGO ontologyBLASTP
43862174386522306hypothetical proteinBLASTP
43865524386899348hypothetical protein
43872404387509270ribonuclease inhibitorQuickGO ontologyBLASTP
43877914388060270hypothetical protein
43892544389544291hypothetical protein
43895934389862270hypothetical protein
43899194390131213hypothetical protein
43901224390649528partial replication initiator proteinQuickGO ontologyBLASTP
43906524390861210excisionaseQuickGO ontologyBLASTP
439086143920001140integraseQuickGO ontologyBLASTP
439227443936171344hypothetical protein 2SC10A702cQuickGO ontology
439400343951331131lipoproteinQuickGO ontology
43951004395579480hypothetical protein 2SC10A704cQuickGO ontology