Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:4031299 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
40312994032045747two-component system regulatorQuickGO ontologyBLASTP
403204240333671326two-component system sensor kinaseQuickGO ontologyBLASTP
403345640351201665spermidine synthaseQuickGO ontologyBLASTP
40352524035809558hypothetical proteinBLASTP
40359964036406411hypothetical protein
403668940378791191hypothetical proteinBLASTP
40379754038511537hypothetical proteinBLASTP
403863740402801644hypothetical proteinBLASTP
404045040430472598ATP-dependent protease ATP-binding subunitQuickGO ontologyBLASTP
40433304043665336hypothetical proteinBLASTP
40436674043858192hypothetical protein
404399140450011011regulatory proteinQuickGO ontologyBLASTP
40449984045981984regulatory proteinQuickGO ontologyBLASTP
404594440471281185regulatory proteinQuickGO ontologyBLASTP
404713840482561119secreted solute-binding proteinQuickGO ontologyBLASTP
40484604048915456heat shock proteinQuickGO ontologyBLASTP
404892140501201200molecular chaperoneQuickGO ontologyBLASTP
40501634050840678heat chock proteinQuickGO ontologyBLASTP
405083740526931857molecular chaperone DnaKQuickGO ontologyBLASTP
405278940540241236cell surface biosynthesis associated proteinQuickGO ontology