Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:3817000 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
38171533817770618transmembrane proteinQuickGO ontology
38177453818494750integral membrane proteinQuickGO ontologyBLASTP
38184913819354864hypothetical potein SCE4616cQuickGO ontology
381941538209321518oxidoreductaseQuickGO ontologyBLASTP
38209293821387459integral membrane proteinQuickGO ontology
382138738228231437hypothetical protein
38228503823638789phosphorylaseQuickGO ontologyBLASTP
38236773824309633hypothetical proteinBLASTP
38243063825016711hypothetical proteinBLASTP
38253713826210840transposaseQuickGO ontologyBLASTP
38264733827312840transposaseQuickGO ontologyBLASTP
382745738289621506transposaseQuickGO ontologyBLASTP
382904338305841542transposaseQuickGO ontologyBLASTP
38306983831525828transposaseQuickGO ontologyBLASTP
38317053832634930extracellular agarase precursorQuickGO ontology
38329883833251264transposase remnantQuickGO ontologyBLASTP
38340553834702648aldolaseQuickGO ontologyBLASTP
383474138357421002sugar kinaseQuickGO ontologyBLASTP
383587038370031134isomeraseQuickGO ontologyBLASTP
38372163837971756short-chain dehydrogenaseQuickGO ontologyBLASTP
383796838390021035dehydrogenaseQuickGO ontologyBLASTP
383899938400331035dehydrogenaseQuickGO ontologyBLASTP
384039538433822988beta-galatosidaseQuickGO ontologyBLASTP
384352338446081086racemaseQuickGO ontologyBLASTP
384467038457821113hypothetical proteinBLASTP
38458093846690882sugar-permeaseQuickGO ontologyBLASTP
38467023847649948integral membrane transport proteinQuickGO ontologyBLASTP
384768538489951311secreted sugar-binding proteinQuickGO ontologyBLASTP
384917738502261050lacI-family transcriptional regulatorQuickGO ontologyBLASTP
385038838518661479aldehyde dehydrogenaseQuickGO ontologyBLASTP
385224938546452397hydrolaseQuickGO ontologyBLASTP