Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:3602753 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
360275336039071155integraseQuickGO ontologyBLASTP
36039073604107201excisionaseQuickGO ontologyBLASTP
360410436055041401replication initiator proteinQuickGO ontologyBLASTP
36055943605911318SpdD proteinQuickGO ontology
36059353606090156SpdC proteinQuickGO ontologyBLASTP
36061023606263162SpdB proteinQuickGO ontologyBLASTP
36063263606979654SpdA proteinQuickGO ontologyBLASTP
360706136084161356plasmid transfer proteinQuickGO ontologyBLASTP
36084203608776357regulatory proteinQuickGO ontologyBLASTP
36089163609695780korSA regulatory proteinQuickGO ontologyBLASTP
36097893610178390MutT-like proteinQuickGO ontologyBLASTP
361087636121711296ATP-binding proteinQuickGO ontologyBLASTP
36121683612917750hypothetical proteinBLASTP
36133323613631300hypothetical proteinBLASTP
36136283614359732gntR-family regulatorQuickGO ontologyBLASTP
36143683614592225hypothetical proteinBLASTP
36145893614792204hypothetical proteinBLASTP
36148343615034201hypothetical protein
36151223615400279secreted proteinQuickGO ontologyBLASTP
36154803616235756gntR-family regulatorQuickGO ontologyBLASTP
36162863616798513hypothetical proteinBLASTP
36170753617377303dehydrogenaseQuickGO ontology
36176123617980369DNA-binding proteinQuickGO ontologyBLASTP
36182133618479267hypothetical proteinBLASTP
36184763618922447hypothetical proteinBLASTP
36190173619469453merR-family transcriptional regulatorQuickGO ontologyBLASTP
361989236213911500integral membrane transporterQuickGO ontologyBLASTP
36214043622270867phosphotransferaseQuickGO ontology
36224653622593129hypothetical protein
362259036238041215integral membrane efflux proteinQuickGO ontologyBLASTP
36238013624412612hypothetical proteinBLASTP
36244493624859411hypothetical proteinBLASTP
36250073625663657precorrin-8X methylmutaseQuickGO ontologyBLASTP
36256953626462768precorrin-6x reductaseQuickGO ontologyBLASTP