Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:32134 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3152032137618hypothetical protein
32134333571224glycosyl transferaseQuickGO ontologyBLASTP
3336033845486integral membrane proteinQuickGO ontology
3384234777936hypothetical proteinBLASTP
3517935907729hypothetical proteinBLASTP
3600636674669oxidoreductaseQuickGO ontologyBLASTP
3668936817129hypothetical protein
3681637478663hydrolaseQuickGO ontologyBLASTP
37614387681155transcriptional regulatorQuickGO ontologyBLASTP
3910739490384hypothetical proteinBLASTP
3948939812324hypothetical protein
3987740212336hypothetical proteinBLASTP
42171436821512membrane-associated oxidoreductaseQuickGO ontologyBLASTP
437684385790hypothetical protein
4395044090141hypothetical proteinBLASTP
4425344975723hypothetical protein
4526746073807zinc-binding oxidoreductaseQuickGO ontologyBLASTP
4606446201138hypothetical protein
46430477341305hypothetical proteinBLASTP
47789488921104LacI family transcriptional regulatorQuickGO ontologyBLASTP
4888949824936glucokinaseQuickGO ontologyBLASTP
49821515391719hypothetical proteinBLASTP