Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:3111998 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
311199831134311434transmembrane efflux proteinQuickGO ontologyBLASTP
311364331146591017hypothetical proteinBLASTP
31147653115223459hypothetical proteinBLASTP
31153443115688345membrane proteinQuickGO ontology
31157033115960258hypothetical protein
31159573116334378hypothetical proteinBLASTP
31165213116931411rifampin ADP-ribosyl transferaseQuickGO ontologyBLASTP
31171593117881723hypothetical protein
31179783118211234hypothetical protein
311836231211992838helicaseQuickGO ontologyBLASTP
31213443121892549hypothetical proteinBLASTP
31220913122933843regulatory proteinQuickGO ontologyBLASTP
31232233123477255hypothetical protein
31236793123906228hypothetical proteinBLASTP
31239143124393480hypothetical proteinBLASTP
31244173125262846regulatory proteinQuickGO ontologyBLASTP
31253343125630297hypothetical protein
31256343126614981hypothetical proteinBLASTP
312661131278431233hypothetical proteinBLASTP
31278943128439546hypothetical proteinBLASTP
31286193129590972oxidoreductaseQuickGO ontologyBLASTP
31296703130077408MerR-family transcriptional regulatorQuickGO ontologyBLASTP
31301053130731627acetyltransferaseQuickGO ontologyBLASTP
31308253131211387membrane proteinQuickGO ontology
313135031338992550hypothetical protein
313461831362731656hypothetical proteinBLASTP