Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:211748 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2101832117511569nitrate reductase beta chain NarH2QuickGO ontologyBLASTP
211748212551804nitrate reductase delta chain NarJ2QuickGO ontologyBLASTP
212551213321771nitrate reductase delta chain NarI2QuickGO ontologyBLASTP
213427213870444hypothetical proteinBLASTP
214913215446534acetyltransferaseQuickGO ontologyBLASTP
215443215559117hypothetical protein
2158072168441038hypothetical proteinBLASTP
216834217268435hypothetical protein
217315218019705hypothetical protein
218418218780363hypothetical protein
21897321905987hypothetical proteinBLASTP
219302220150849short chain dehydrogenaseQuickGO ontologyBLASTP
220150220764615tetR-family transcriptional regulatorQuickGO ontologyBLASTP
221092221247156small hydrophobic hypothetical proteinQuickGO ontology
221414221599186hypothetical protein
221699222538840DNA-binding proteinQuickGO ontologyBLASTP
222827223288462oxidoreductaseQuickGO ontologyBLASTP
223294224232939short chain dehydrogenaseQuickGO ontologyBLASTP
224404225276873DNA-binding proteinQuickGO ontologyBLASTP
225476226237762oxidoreductaseQuickGO ontologyBLASTP
226481227008528hypothetical proteinBLASTP
2270812281541074hypothetical proteinBLASTP
228714229649936oxidoreductaseQuickGO ontologyBLASTP
229995230669675transcriptional regulatorQuickGO ontologyBLASTP
231022231465444hypothetical proteinBLASTP
231475231654180hypothetical protein
2325082335181011secreted proteinQuickGO ontologyBLASTP