Pre_GI Gene

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Host: NC_003888 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003888:1751179 Streptomyces coelicolor A3(2), complete genome

Host Lineage: Streptomyces coelicolor; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: Well-studied antiobiotic-producing bacterium. These bacteria are widely distributed in nature, especially in the soil. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This bacterium is a soil-dwelling filamentous organism responsible for producing more than half of the known natural antibiotics. It is a well-studied species of Streptomyces and genetically is the best known representative.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
17511791752132954hypothetical proteinBLASTP
17522701752641372peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
175270117537081008secreted peptidyl-prolyl cis-trans isomerase proteinQuickGO ontologyBLASTP
175389017552511362hypothetical proteinBLASTP
175526117564781218transport proteinQuickGO ontologyBLASTP
175658217576341053LacI family regulatorQuickGO ontologyBLASTP
1757649175841376520S proteasome alpha-subunitQuickGO ontologyBLASTP
1758475175932084620S proteasome beta-subunit precursorQuickGO ontologyBLASTP
17592721759865594hypothetical proteinBLASTP
17598991760117219hypothetical proteinBLASTP
176029617617891494hypothetical proteinBLASTP
176204017638061767AAA ATPaseQuickGO ontologyBLASTP
17640521764357306ferredoxinQuickGO ontologyBLASTP
17644321765022591secreted proteinQuickGO ontologyBLASTP
17652571766159903hypothetical proteinBLASTP
176628717674111125hypothetical proteinBLASTP
17682851769139855hypothetical proteinBLASTP
17691561769827672two-component response regulatorQuickGO ontologyBLASTP
176994617715501605lipoprotein oligopeptide binding proteinQuickGO ontologyBLASTP