Pre_GI Gene

Some Help

Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:981105 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
981105981845741hypothetical proteinBLASTP
9820279832711245hypothetical proteinBLASTP
983406983933528hypothetical proteinBLASTP
984452984919468hypothetical proteinBLASTP
985047985406360hypothetical proteinBLASTP
985384985761378hypothetical proteinBLASTP
9859459878191875histidinol-phosphataseQuickGO ontologyBLASTP
9881149899461833cyclomaltodextrinaseQuickGO ontologyBLASTP
9901919914741284hypothetical proteinBLASTP
991753992256504hypothetical proteinBLASTP
992576993121546hypothetical proteinBLASTP
993161993781621hypothetical proteinBLASTP
994044994988945probable ironIII dicitrate ABC transporterQuickGO ontologyBLASTP
9950879961001014probable ferrichrome ABC transporterQuickGO ontologyBLASTP
9961049971171014probable ferrichrome ABC transporterQuickGO ontologyBLASTP
997182997964783probable ferrichrome ABC transporterQuickGO ontologyBLASTP
998264998752489hypothetical proteinBLASTP
998829999044216hypothetical proteinBLASTP
999037999354318hypothetical proteinBLASTP
999566999892327hypothetical protein