Pre_GI Gene

Some Help

Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:64908 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
6490865813906D-3-phosphoglycerate dehydrogenaseQuickGO ontologyBLASTP
65960672161257hypothetical proteinBLASTP
6727267967696nucleoside phosphorylaseQuickGO ontologyBLASTP
6834769108762hypothetical proteinBLASTP
69399705651167hypothetical proteinBLASTP
7059071528939probable ribosomal-protein S5-alanine N-acetyltransferaseQuickGO ontologyBLASTP
7154572231687probable deoxyguanosine kinaseQuickGO ontologyBLASTP
78534798561323probable integral membrane transport proteinQuickGO ontologyBLASTP
7998380132150hypothetical protein
80480825042025glycogen branching enzymeQuickGO ontologyBLASTP
82532839801449glycogen synthaseQuickGO ontologyBLASTP
84010864452436glycogen phosphorylaseQuickGO ontologyBLASTP
86541883611821amylopullulanaseQuickGO ontologyBLASTP
8841688859444hypothetical proteinBLASTP
89069902501182glucose-1-phosphate adenylyltransferaseQuickGO ontologyBLASTP
90280913861107glycogen biosynthesis proteinQuickGO ontologyBLASTP
9144991895447probable phosphotransbutyrylaseQuickGO ontologyBLASTP
92062935041443probable cardiolipin synthaseQuickGO ontologyBLASTP
93936954921557hypothetical proteinBLASTP
101425102009585probable transcription antiterminatorQuickGO ontologyBLASTP
101897102274378probable transcription antiterminatorQuickGO ontologyBLASTP
102497102754258hypothetical proteinBLASTP
1034471046641218probable PTS system enzymeQuickGO ontologyBLASTP
104712104897186hypothetical proteinBLASTP
104966105484519probable transcriptional regulatorQuickGO ontologyBLASTP
1115851136752091translation elongation factor EF-GQuickGO ontologyBLASTP