Pre_GI Gene

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Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:255480 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
2554802568051326maltose-6-phosphate glucosidaseQuickGO ontologyBLASTP
257386257547162hypothetical proteinBLASTP
257764258627864probable acid phosphataseQuickGO ontologyBLASTP
2588492600481200probable cell wall-binding proteinQuickGO ontologyBLASTP
260735261391657hypothetical proteinBLASTP
267399268028630probable acetyltransferaseQuickGO ontologyBLASTP
268495268770276hypothetical proteinBLASTP
270353270934582hypothetical proteinBLASTP
2710732734482376two-component sensor histidine kinaseQuickGO ontologyBLASTP
2738152748731059hypothetical proteinBLASTP
274974275201228hypothetical proteinBLASTP
275341276222882hypothetical proteinBLASTP
2762502784482199hypothetical proteinBLASTP
278930279700771hypothetical proteinBLASTP
279879280694816hypothetical proteinBLASTP
281268281912645probable heme oxygenaseQuickGO ontologyBLASTP
2823132835361224probable exonucleaseQuickGO ontologyBLASTP
2835142870413528probable exonucleaseQuickGO ontologyBLASTP
2874462886421197acetate kinaseQuickGO ontologyBLASTP
289079289900822DnaJ-related proteinQuickGO ontologyBLASTP
290151290909759probable transcriptional regulatorQuickGO ontologyBLASTP
2910562932872232hypothetical proteinBLASTP
293350293997648hypothetical proteinBLASTP
293999294562564hypothetical proteinBLASTP
294576295463888ferrichrome ABC transporterQuickGO ontologyBLASTP
295450296436987ferrichrome ABC transporterQuickGO ontologyBLASTP
296437297216780ferrichrome ABC transporterQuickGO ontologyBLASTP