Pre_GI Gene

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Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:2494907 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
249490724971412235exodeoxyribonuclease V alpha subunitQuickGO ontologyBLASTP
249727824984141137N-acetylglucosamine-6-phosphate deacetylaseQuickGO ontologyBLASTP
249855424995791026S-adenosylmethionine synthetaseQuickGO ontologyBLASTP
25009462501590645hypothetical proteinBLASTP
25016962502226531hypothetical proteinBLASTP
250226525033021038cell shape determining proteinQuickGO ontologyBLASTP
25033932503644252stage III sporulation protein DQuickGO ontologyBLASTP
25037192504489771hypothetical proteinBLASTP
250460625056281023stage II sporulation protein DQuickGO ontologyBLASTP
250574025070051266UDP-N-acetylglucosamine 1-carboxyvinyltransferaseQuickGO ontologyBLASTP
25070282507672645hypothetical proteinBLASTP
25078542508255402ATP synthase epsilon subunitQuickGO ontologyBLASTP
250827125096681398ATP synthase subunit BQuickGO ontologyBLASTP
25096822510533852ATP synthase gamma subunitQuickGO ontologyBLASTP
251059825121061509ATP synthase subunit AQuickGO ontologyBLASTP
25121172512656540ATP synthase subunit DQuickGO ontologyBLASTP
25126592513138480ATP synthase B chainQuickGO ontologyBLASTP
25132382513456219ATP synthase C chainQuickGO ontologyBLASTP
25135172514191675ATP synthase subunit AQuickGO ontologyBLASTP
25142472514612366hypothetical proteinBLASTP
251529425164721179acetyl-CoA acetyltransferaseQuickGO ontologyBLASTP
251674125178951155UDP-N-acetylglucosamine 2-epimeraseQuickGO ontologyBLASTP
25179592518588630uracil phosphoribosyltransferaseQuickGO ontologyBLASTP