Pre_GI Gene

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Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:1427785 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
14277851428396612precorrin-6Y methylaseQuickGO ontologyBLASTP
142842414295211098cobalt-precorrin-6A synthaseQuickGO ontologyBLASTP
14295391430168630precorrin-8X methylmutaseQuickGO ontologyBLASTP
14301681431010843CbiK proteinQuickGO ontologyBLASTP
143153014327621233hypothetical proteinBLASTP
14327821433090309hypothetical protein
143335814367473390probable surface proteinQuickGO ontologyBLASTP
143712114381221002hypothetical proteinBLASTP
14381561438854699hypothetical proteinBLASTP
143936514423703006hyaluronidaseQuickGO ontologyBLASTP
14425981443551954hypothetical proteinBLASTP
14437831444466684superoxide dismutaseQuickGO ontologyBLASTP
14445281445139612hypothetical protein
144544914468971449probable multidrug resistance proteinQuickGO ontologyBLASTP
14469571447121165hypothetical protein
144715214484891338probable magnesium transporterQuickGO ontologyBLASTP
14490301449803774hypothetical proteinBLASTP
14500661450275210cold shock proteinQuickGO ontologyBLASTP