Pre_GI Gene

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Host: NC_003366 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003366:1122654 Clostridium perfringens str. 13, complete genome

Host Lineage: Clostridium perfringens; Clostridium; Clostridiaceae; Clostridiales; Firmicutes; Bacteria

General Information: This strain is a type A isolate from the soil. It can establish gas gangrene in a murine experimental model. Causative agent of gas gangrene. This genus comprises about 150 metabolically diverse species of anaerobes that are ubiquitous in virtually all anoxic habitats where organic compounds are present, including soils, aquatic sediments and the intestinal tracts of animals and humans. This shape is attributed to the presence of endospores that develop under conditions unfavorable for vegetative growth and distend single cells terminally or sub-terminally. Spores germinate under conditions favorable for vegetative growth, such as anaerobiosis and presence of organic substrates. It is believed that present day Mollicutes (Eubacteria) have evolved regressively (i.e., by genome reduction) from gram-positive clostridia-like ancestors with a low GC content in DNA. This organism is a causative agent of a wide spectrum of necrotic enterotoxicoses. It also causes such animal diseases as lamb dysentery, ovine enterotoxemia (struck), pulpy kidney disease in lambs and other enterotoxemias in lambs and calves. It is commonly found in the environment (soil, sewage) and in the animal and human gastrointestinal tract as a member of the normal microflora. It is a fast growing (generation time 8-10 min) anaerobic flesh-eater. Active fermentative growth is accompanied by profuse generation of molecular hydrogen and carbon dioxide. It is also oxygen tolerant which makes it an easy object to work with in laboratories. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. Known isolates belong to five distinct types (A, B, C, D, and E) that are distinguished based on the specific extracellular toxins they produce. All types produce the alpha toxin (phospholipase C). Type A strains that cause gas gangrene produce alpha toxin, theta (hemolysin), kappa (collagenase), mu (hyaluronidase), nu (DNAse) and neuraminidase which are all the enzymatic factors aiding the bacterium in invading and destruction of the host tissues. Type C strains produce alpha toxin, beta toxin and prefringolysin enteritis. In addition to alpha toxin, Type B strains produce beta toxin, types B and D produce the pore forming epsilon toxin and type E strains produce iota toxin.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
11226541123067414hypothetical proteinBLASTP
11231361123966831hypothetical proteinBLASTP
11241421124318177hypothetical proteinBLASTP
11245471125251705glycerol uptake facilitator proteinQuickGO ontologyBLASTP
112543811266701233two-component sensor histidine kinaseQuickGO ontologyBLASTP
11266901127442753two-component response regulatorQuickGO ontologyBLASTP
112778011294441665coenzyme B12-dependent glycerol dehydrogenase large subunitQuickGO ontologyBLASTP
11294521130024573coenzyme B12-dependent glycerol dehydrogenase medium subunitQuickGO ontologyBLASTP
11300441130469426coenzyme B12-dependent glycerol dehydrogenase small subunitQuickGO ontologyBLASTP
113048611323361851probable glycerol dehydratase large subunitQuickGO ontologyBLASTP
11323291132679351hypothetical proteinBLASTP
11326981133210513hypothetical proteinBLASTP
11332341133662429hypothetical proteinBLASTP
11337561134913115813-propanediol dehydrogenaseQuickGO ontologyBLASTP
113549811369671470hypothetical proteinBLASTP
11372561137930675hypothetical proteinBLASTP
11382711138783513probable acetyltransferaseQuickGO ontologyBLASTP
11388511139621771hypothetical proteinBLASTP
11397271140545819hypothetical proteinBLASTP