Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:921494 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
921494922408915LysR-family transcriptional regulatorQuickGO ontologyBLASTP
922521922928408GntR-family transcriptional regulatorQuickGO ontologyBLASTP
922853923590738hypothetical proteinBLASTP
9237789253701593monooxygenaseQuickGO ontologyBLASTP
925541926167627TetR-family transcriptional regulatorQuickGO ontologyBLASTP
926268926516249hypothetical protein
926586927077492hypothetical proteinBLASTP
9275249285551032hypothetical proteinBLASTP
928799928972174transposaseQuickGO ontology
929152930075924monooxygenaseQuickGO ontologyBLASTP
930473930895423hypothetical protein
930904931179276hypothetical protein
931759932133375hypothetical protein
932225932773549hypothetical protein
934229934714486hypothetical proteinBLASTP
9359539387272775magnesium or manganese-dependent protein phosphataseQuickGO ontologyBLASTP
939117939773657hypothetical proteinBLASTP
940165940638474hypothetical proteinBLASTP
9409109423491440aldehyde dehydrogenaseQuickGO ontologyBLASTP
942366942767402hypothetical protein
9428469443811536transmembrane transport proteinQuickGO ontologyBLASTP