Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:7979050 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
797905079806541605lipoprotein oligopeptide binding proteinQuickGO ontologyBLASTP
798074079823231584solute binding transport lipoproteinQuickGO ontologyBLASTP
79824137983084672two-component system response regulatorQuickGO ontologyBLASTP
79831017983961861hypothetical proteinBLASTP
798495079860801131peptidaseQuickGO ontologyBLASTP
79861217987023903hypothetical proteinBLASTP
79872137987788576hypothetical proteinBLASTP
79878687988173306ferredoxinQuickGO ontologyBLASTP
798842879901941767AAA-family ATPaseQuickGO ontologyBLASTP
799043079919411512proteasome componentQuickGO ontologyBLASTP
79920977992315219hypothetical proteinBLASTP
79923347992942609endonuclease VIIQuickGO ontologyBLASTP
7992894799373984620S proteasome beta-subunitQuickGO ontologyBLASTP
7993807799456876220S proteasome alpha-subunitQuickGO ontologyBLASTP
799462579956411017LacI-family transcriptional regulatorQuickGO ontologyBLASTP
799576379970221260transmembrane transport proteinQuickGO ontologyBLASTP
799703279983931362proteasome componentQuickGO ontologyBLASTP
799852379995271005FK-506 binding protein peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
79995997999973375FK-506 binding protein peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
80001938001170978hypothetical proteinBLASTP
800118780022271041hypothetical proteinBLASTP
80022248002604381hypothetical protein