Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:777216 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
777216778127912LysR-family transcriptional regulatorQuickGO ontologyBLASTP
778334779140807hypothetical proteinBLASTP
7795547810291476glycosyl hydrolaseQuickGO ontologyBLASTP
7810507826601611secreted alpha-galactosidaseQuickGO ontologyBLASTP
782844783239396hypothetical proteinBLASTP
7838857849401056LacI-family transcriptional regulatorQuickGO ontologyBLASTP
785031785402372hypothetical protein
785356785871516hypothetical protein
786451786915465hypothetical protein
7882487893121065IS110 family transposaseQuickGO ontologyBLASTP
789498790355858enoyl-CoA hydrataseQuickGO ontologyBLASTP
790843791451609AraC-family transcriptional regulatorQuickGO ontologyBLASTP
792236792676441hypothetical protein
793192794145954hypothetical proteinBLASTP
794749795285537serinethreonine protein kinaseQuickGO ontologyBLASTP