Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:7453994 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
74532067454036831short chain dehydrogenaseQuickGO ontologyBLASTP
74539947454941948short chain dehydrogenaseQuickGO ontologyBLASTP
74553947456320927hypothetical proteinBLASTP
74564327457328897hypothetical proteinBLASTP
74574857458360876trypsinogen precursorQuickGO ontologyBLASTP
74585727459027456acetyltransferaseQuickGO ontologyBLASTP
74591887459577390chorismate mutaseQuickGO ontologyBLASTP
74597067460263558two-component system response regulatorQuickGO ontologyBLASTP
746035574628952541aminopeptidaseQuickGO ontologyBLASTP
746314374645851443amino acid decarboxylaseQuickGO ontologyBLASTP
746458274660001419monooxygenaseQuickGO ontologyBLASTP
74660977467917182123-cyclic-nucleotide 2-phosphodiesteraseQuickGO ontologyBLASTP
74680077468768762hypothetical proteinBLASTP
746893774703731437pyruvate kinaseQuickGO ontologyBLASTP
74703857471197813hypothetical proteinBLASTP
74714447472100657two-component system response regulatorQuickGO ontologyBLASTP
74722047472920717branched-chain amino acid ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
74729177473861945branched-chain amino acid ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
747385874756331776branched-chain amino acid ABC transporter permease proteinQuickGO ontologyBLASTP
74756397476571933branched-chain amino acid ABC transporter permease proteinQuickGO ontologyBLASTP
747668374779121230periplasmic branched-chain amino acid-binding proteinQuickGO ontologyBLASTP
74788327479293462hypothetical proteinBLASTP
747936074816422283formate dehydrogenaseQuickGO ontologyBLASTP