Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:6667928 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
666676866679311164DNA-binding proteinQuickGO ontologyBLASTP
666792866704502523hypothetical proteinBLASTP
66705116670789279hypothetical protein
66711966671525330hypothetical protein
66715986671918321hypothetical protein
66720346672387354hypothetical protein
66725296673287759GntR-family transcriptional regulatorQuickGO ontologyBLASTP
66734736674246774N-acetylmuramoyl-L-alanine amidase precursorQuickGO ontologyBLASTP
66743236674634312hypothetical protein
66746496674873225hypothetical protein
66748756675222348hypothetical protein
66753136676260948hypothetical protein
66763646676564201hypothetical protein
667658566782731689hypothetical proteinBLASTP
667830366793311029hypothetical proteinBLASTP
667934566805351191hypothetical proteinBLASTP
66805396681474936hypothetical proteinBLASTP
668149666849243429phage minor tail proteinQuickGO ontologyBLASTP
66849686685366399hypothetical protein
66854656685797333hypothetical protein
66859516686568618phage major tail proteinQuickGO ontologyBLASTP
66866296687072444hypothetical protein
66870916687330240hypothetical protein
66873346687618285hypothetical protein
66876186687959342hypothetical protein
66879636688358396hypothetical protein
66883786688713336hypothetical protein
668874466900661323hypothetical proteinBLASTP
66900826690711630phage minor structural proteinQuickGO ontology
669075366923301578phage minor capsid proteinQuickGO ontologyBLASTP
669232766936251299phage-related terminase large subunitQuickGO ontologyBLASTP
66936296694117489hypothetical protein
66946056694850246hypothetical protein
66950246695500477hypothetical protein
66955166695725210MerR-family transcriptional regulatorQuickGO ontology
66958616696484624hypothetical protein
66965836697143561hypothetical protein
66972576697772516hypothetical protein
66978616698022162hypothetical protein
66980326698700669hypothetical proteinBLASTP
66987186699254537hypothetical proteinBLASTP
66992516699643393hypothetical protein
66997136700657945hypothetical protein
67007776701424648hypothetical proteinBLASTP
67020426702266225hypothetical protein
670226367038101548type II restriction-modification system DNA cytosine-specific methylaseQuickGO ontologyBLASTP
67037916704228438hypothetical protein
67042256704467243hypothetical protein
67044646704691228hypothetical protein
67046886705548861hypothetical protein
670577267072291458hypothetical protein
67076666708007342hypothetical protein
67083086708553246hypothetical protein
67085626708810249hypothetical protein
67087896708980192hypothetical protein
67090426709416375hypothetical protein
67095056710344840hypothetical proteinBLASTP
671034667118481503integraserecombinaseQuickGO ontologyBLASTP