Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:6295078 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
62950786295557480hypothetical protein
62956426296151510hypothetical protein
62961626296611450integral membrane proteinQuickGO ontologyBLASTP
629688262979071026AraC-family transcriptional regulatorQuickGO ontologyBLASTP
62979846298289306hypothetical proteinBLASTP
62984446299172729hypothetical proteinBLASTP
62993856299759375hypothetical protein
62999766300449474hypothetical proteinBLASTP
63010086301202195hypothetical proteinBLASTP
63011776301710534hypothetical proteinBLASTP
63017366302587852DNA-binding proteinQuickGO ontologyBLASTP
63026306303106477hypothetical protein
63032686303480213hypothetical proteinBLASTP
63034776304325849DNA-binding proteinQuickGO ontologyBLASTP
63045326305194663hypothetical proteinBLASTP
630519863081192922ATP-dependent helicaseQuickGO ontologyBLASTP
63090506309583534hypothetical proteinBLASTP
630963163106441014hypothetical proteinBLASTP
631084763123221476secreted endo-beta-16-galactanaseQuickGO ontologyBLASTP
63126016313419819hypothetical proteinBLASTP
63135866313921336hypothetical proteinBLASTP
63140346314765732hypothetical proteinBLASTP
631490863157658582-hydroxyhepta-24-diene-17-dioate isomeraseQuickGO ontologyBLASTP
63159256316416492hypothetical proteinBLASTP
631648563175791095oxidoreductaseQuickGO ontologyBLASTP
631763963189251287ROK-family transcriptional regulatorQuickGO ontologyBLASTP
631918763202061020hypothetical proteinBLASTP
63203086321087780N-acetyl-glucosamine catabolism proteinQuickGO ontologyBLASTP