Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:622993 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
622993623559567hypothetical proteinBLASTP
6243446254321089regulatory proteinQuickGO ontologyBLASTP
625518626249732transposaseQuickGO ontologyBLASTP
626420627271852methyltransferaseQuickGO ontologyBLASTP
627377627523147hypothetical protein
627541628107567hypothetical proteinBLASTP
628625628882258hypothetical proteinBLASTP
629473629790318hypothetical proteinBLASTP
629806630354549IS630 family transposaseQuickGO ontologyBLASTP
630351630686336IS630 family transposaseQuickGO ontologyBLASTP
630951631274324hypothetical protein
631222631539318hypothetical protein
631562631783222hypothetical protein
631817632638822ubiECOQ5 methyltransferase family proteinQuickGO ontologyBLASTP
632948633259312hypothetical protein
633243633470228hypothetical protein
633937634218282hypothetical protein
634378635061684TetR-family transcriptional regulatorQuickGO ontologyBLASTP
635181635900720hypothetical proteinBLASTP
636261636563303hypothetical protein
636931637317387transcriptional regulatorQuickGO ontologyBLASTP
637423638256834enoyl-CoA hydrataseQuickGO ontologyBLASTP
639053639388336hypothetical protein
640006640821816hypothetical proteinBLASTP
641145641333189hypothetical protein
641343641822480hypothetical proteinBLASTP
642389642613225integraserecombinaseQuickGO ontologyBLASTP
642610643092483integraserecombinaseQuickGO ontologyBLASTP
643080643727648hypothetical proteinBLASTP
643739644002264hypothetical protein
644154645011858nucleaseQuickGO ontologyBLASTP
645222645671450hypothetical protein
646464646712249hypothetical protein
646906647130225translation initiation factor IF-1QuickGO ontologyBLASTP
648107648520414IS402-like transposaseQuickGO ontologyBLASTP
648664649314651monooxygenaseQuickGO ontologyBLASTP
650027650887861hypothetical proteinBLASTP
6523006533551056cinnamoyl-CoA reductaseQuickGO ontologyBLASTP
653742654326585TetR-family transcriptional regulatorQuickGO ontologyBLASTP