Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:590500 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5906785917781101hypothetical proteinBLASTP
592072592773702hypothetical proteinBLASTP
5942325952481017DNA-directed RNA polymerase alpha subunitQuickGO ontologyBLASTP
595471596031561IS3L-like transposaseQuickGO ontologyBLASTP
596538596843306hypothetical proteinBLASTP
596972597148177hypothetical proteinBLASTP
5983126007742463cell wall-associated proteinQuickGO ontologyBLASTP
601030601425396Tn4561 family transposaseQuickGO ontologyBLASTP
601349601615267IS630 family transposaseQuickGO ontology
601641601862222IS630 family transposaseQuickGO ontologyBLASTP
602829603446618TetR-family transcriptional regulatorQuickGO ontologyBLASTP
603569603973405hypothetical proteinBLASTP
604002604904903hypothetical proteinBLASTP
605005605373369anti-sigma factor antagonistQuickGO ontologyBLASTP
605510606031522hypothetical protein
606058606540483hypothetical proteinBLASTP
6066856078391155hypothetical proteinBLASTP
607861608373513hypothetical protein
608423609064642hypothetical protein
6090366107031668hypothetical proteinBLASTP