Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:5443230 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
544323054449211692hypothetical proteinBLASTP
544550854466951188hypothetical proteinBLASTP
544706054483671308hypothetical proteinBLASTP
544947454507331260UDP-glucoseGDP-mannose dehydrogenaseQuickGO ontologyBLASTP
545110954524281320glycosyl transferaseQuickGO ontologyBLASTP
54533545453929576deoxycytidine triphosphate deaminaseQuickGO ontologyBLASTP
54539505454459510purine phosphoribosyltransferaseQuickGO ontologyBLASTP
54556315456419789IS1648-like transposaseQuickGO ontologyBLASTP
54564165457267852rRNA methyltransferaseQuickGO ontologyBLASTP
545766854591011434integraserecombinaseQuickGO ontologyBLASTP
545930654603191014hypothetical proteinBLASTP
54603935460908516regulatory proteinQuickGO ontologyBLASTP
54609895461831843DNA-binding proteinQuickGO ontologyBLASTP
54618435462028186hypothetical protein
546206954635051437integrin-like proteinQuickGO ontologyBLASTP