Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:5302280 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
530228053039741695serinethreonine protein kinaseQuickGO ontologyBLASTP
53041745304722549DNA-binding proteinQuickGO ontologyBLASTP
5304905530497773tRNA-AlaQuickGO ontology
53053865306087702regulatory proteinQuickGO ontologyBLASTP
53064915307051561peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
53072775308173897hypothetical proteinBLASTP
53084565308710255hypothetical proteinBLASTP
53088535309665813hypothetical proteinBLASTP
53097125310404693hypothetical proteinBLASTP
53104095310597189hypothetical proteinBLASTP
53105945311232639para-aminobenzoate synthase component IIQuickGO ontologyBLASTP
531122953125781350hypothetical proteinBLASTP
53125925313332741hypothetical proteinBLASTP
531339553153982004serinethreonine protein kinaseQuickGO ontologyBLASTP
531556953170531485penicillin-binding proteinQuickGO ontologyBLASTP
531705053184981449cell division membrane proteinQuickGO ontologyBLASTP
531852553200691545magnesium or manganese-dependent protein phosphataseQuickGO ontologyBLASTP
53201905320717528hypothetical proteinBLASTP
53207285321585858hypothetical proteinBLASTP