Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:4906639 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
490663949079551317phage-related integraseQuickGO ontologyBLASTP
49079554908194240hypothetical proteinBLASTP
490818749095541368replication initiation proteinQuickGO ontologyBLASTP
49096274909908282SpdD proteinQuickGO ontology
49099014910095195hypothetical proteinBLASTP
49101124910303192mobile element transfer protein SpdBQuickGO ontologyBLASTP
49103154910944630mobile element transfer protein SpdAQuickGO ontologyBLASTP
491115049124451296plasmid transfer proteinQuickGO ontologyBLASTP
49124454912801357replication activator protein PraQuickGO ontologyBLASTP
49129714913759789regulatory protein KorSA GntR-family transcriptional regulatorQuickGO ontologyBLASTP
49137864914274489MutT-like proteinQuickGO ontologyBLASTP
49142914914755465regulatory proteinQuickGO ontologyBLASTP
49147494915141393hypothetical proteinBLASTP
49151824915616435hypothetical protein
491577949169031125serinethreonine protein kinaseQuickGO ontologyBLASTP
49169804917876897hypothetical proteinBLASTP
49180854918567483hypothetical protein
49188584919292435hypothetical proteinBLASTP
49195654920089525hypothetical protein
492008649210931008hypothetical protein
49214264921935510hypothetical protein
49219004922481582hypothetical proteinBLASTP
49226284922972345hypothetical proteinBLASTP
49231444923956813AraC-family transcriptional regulatorQuickGO ontologyBLASTP
492393549257011767hypothetical protein
49258524926343492hypothetical proteinBLASTP
492633649277301395glycosyl transferaseQuickGO ontologyBLASTP
49278744928692819hypothetical proteinBLASTP
492893549300261092NLPP60-family secreted proteinQuickGO ontologyBLASTP
493033249317801449magnesium or manganese-dependent protein phosphataseQuickGO ontologyBLASTP