Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:4592000 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
45920374592204168hypothetical protein
459239645938711476ATP-binding proteinQuickGO ontologyBLASTP
45938744594734861hypothetical proteinBLASTP
459487545959061032hypothetical proteinBLASTP
45959344596389456hypothetical proteinBLASTP
459655945986372079sporulation-related proteinQuickGO ontologyBLASTP
45986514599220570sporulation-related proteinQuickGO ontologyBLASTP
45992404599740501hypothetical proteinBLASTP
459976946008511083hypothetical protein
46008484601825978hypothetical proteinBLASTP
46018224602112291hypothetical proteinBLASTP
46027274603485759GntR-family transcriptional regulatorQuickGO ontologyBLASTP
460572046070841365IS4 family transposaseQuickGO ontologyBLASTP
460734246083521011hypothetical proteinBLASTP
46088444609239396hypothetical proteinBLASTP
460942046105231104hypothetical proteinBLASTP
461060846123561749hypothetical proteinBLASTP
46127494613219471hypothetical protein
461480146159401140integraseQuickGO ontologyBLASTP
461614546174581314replication initiation proteinQuickGO ontologyBLASTP
46176074617852246SpdD proteinQuickGO ontology
46178774618071195hypothetical proteinBLASTP
46180884618279192mobile element transfer protein SpdBQuickGO ontologyBLASTP
46182924618918627mobile element transfer protein SpdAQuickGO ontologyBLASTP
461900746203861380plasmid transfer proteinQuickGO ontologyBLASTP
46203864620742357replication activator protein PraQuickGO ontologyBLASTP
46209204621708789regulatory protein KorSA GntR-family transcriptional regulatorQuickGO ontologyBLASTP
46217354622223489MutT-like proteinQuickGO ontologyBLASTP
46222704622698429regulatory proteinQuickGO ontologyBLASTP
46226924623039348hypothetical protein
46230364623425390hypothetical proteinBLASTP
462346646252351770ISmav2-like transposaseQuickGO ontologyBLASTP
462652546277301206hypothetical proteinBLASTP
463044346319721530hypothetical protein
46323954632796402hypothetical proteinBLASTP
46330484633491444hypothetical protein
463459746361441548hypothetical proteinBLASTP