Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:4441559 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
444155944430941536hypothetical proteinBLASTP
44431754444062888deoxyribonucleaseQuickGO ontologyBLASTP
44441824444598417hypothetical proteinBLASTP
44449664445832867tetrapyrrole methylaseQuickGO ontologyBLASTP
444589544476341740integral membrane proteinQuickGO ontologyBLASTP
44496424450097456hypothetical proteinBLASTP
44502514451030780hypothetical proteinBLASTP
44512524451962711hypothetical protein
44518804452179300hypothetical protein
44528934453570678hypothetical proteinBLASTP
44541044454766663hypothetical proteinBLASTP
445490544562751371peroxidaseQuickGO ontologyBLASTP
445633044574601131hypothetical proteinBLASTP
445759644589601365glutamate decarboxylaseQuickGO ontologyBLASTP
445906544602071143hypothetical protein
446030444619351632penicillin-binding proteinQuickGO ontologyBLASTP
446202944637021674penicillin-binding proteinQuickGO ontologyBLASTP
44637474464088342cell division protein regulatory proteinQuickGO ontologyBLASTP
446425344653081056ABC-type cobalt transport system permease componentQuickGO ontologyBLASTP