Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:365500 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3668103680001191transposaseQuickGO ontologyBLASTP
368148368522375transposaseQuickGO ontology
3686203696211002IS4 family transposaseQuickGO ontologyBLASTP
369344370132789IS4 family transposaseQuickGO ontologyBLASTP
3710093726371629IS4 family transposaseQuickGO ontologyBLASTP
372788373066279IS3 family transposaseQuickGO ontologyBLASTP
373063373980918IS3 family transposaseQuickGO ontologyBLASTP
374674375111438IS402-like transposaseQuickGO ontologyBLASTP
3756683766811014IS402-like transposaseQuickGO ontologyBLASTP
3768833781571275IS4 family transposaseQuickGO ontologyBLASTP
378281378862582hypothetical proteinBLASTP
3792203804581239magnesium or manganese-dependent protein phosphataseQuickGO ontologyBLASTP
380736381536801hypothetical proteinBLASTP
381592381924333MerR-family transcriptional regulatorQuickGO ontologyBLASTP
383053383349297ArsR-family transcriptional regulatorQuickGO ontologyBLASTP
383431384198768hypothetical proteinBLASTP