Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:3652587 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
365258736539781392diaminopimelate decarboxylaseQuickGO ontologyBLASTP
365400236550601059arginyl-tRNA synthetaseQuickGO ontologyBLASTP
36552203655813594two-component system response regulatorQuickGO ontologyBLASTP
3655871365594272tRNA-ArgQuickGO ontology
365633036577421413hypothetical proteinBLASTP
365781036593391530hypothetical proteinBLASTP
36594193659685267hypothetical protein
366221536640231809hypothetical proteinBLASTP
366468036667342055hypothetical proteinBLASTP
36667313666895165hypothetical protein
366692336690672145DNA repair helicaseQuickGO ontologyBLASTP
36724663672861396hypothetical proteinBLASTP
367283636748632028hypothetical proteinBLASTP
367485036764271578hypothetical proteinBLASTP
367642436775631140hypothetical proteinBLASTP
367780836789621155L-cysteine desulfurase pyridoxal phosphate-dependentQuickGO ontologyBLASTP
367896836804041437hypothetical proteinBLASTP
36831553683652498hypothetical protein
36836913684662972integraseQuickGO ontologyBLASTP
36846433684981339integraseQuickGO ontologyBLASTP
36851593685857699replication initiator proteinQuickGO ontologyBLASTP
36860103686846837secreted metalloproteaseQuickGO ontologyBLASTP
36875933688159567hypothetical proteinBLASTP
36890263689523498hypothetical proteinBLASTP
36895833689798216hypothetical protein
368993736915801644hypothetical protein
3692368369361812513-oxoacyl-ACP synthase IIQuickGO ontologyBLASTP
369374936948491101Ku70Ku80 proteinQuickGO ontologyBLASTP
36948923695773882DNA ligaseQuickGO ontologyBLASTP