Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:3095123 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
309512330990943972FtsKSpoIIIE family proteinQuickGO ontologyBLASTP
30992413099561321BldB proteinQuickGO ontologyBLASTP
309969331009821290hypothetical protein
310101731021051089hypothetical protein
31025493102848300hypothetical protein
31029293103279351hypothetical protein
310339931046161218secreted serine proteaseQuickGO ontologyBLASTP
310471731065041788hypothetical proteinBLASTP
31065013107028528hypothetical proteinBLASTP
31074043107856453hypothetical proteinBLASTP
310786131101612301hypothetical proteinBLASTP
31113083111895588hypothetical protein
311189231131901299serine proteaseQuickGO ontologyBLASTP
311322131147441524hypothetical proteinBLASTP
311497131163081338hypothetical proteinBLASTP
31163083117111804hypothetical proteinBLASTP
311870231211342433hypothetical proteinBLASTP
31212103122004795hypothetical protein