Pre_GI Gene

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Host: NC_003155 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003155:210240 Streptomyces avermitilis MA-4680, complete genome

Host Lineage: Streptomyces avermitilis; Streptomyces; Streptomycetaceae; Actinomycetales; Actinobacteria; Bacteria

General Information: This strain (ATCC 31267) was isolated and characterized in 1978 by R. Burg and colleagues from a soil sample collected in Shizuoka Prefecture, Japan. Antibiotic-producing bacterium. The characteristic earthy smell of freshly plowed soil is actually attributed to the aromatic terpenoid geosmin produced by species of Streptomyces. There are currently 364 known species of this genus, many of which are the most important industrial producers of antibiotics and other secondary metabolites of antibacterial, antifungal, antiviral, and antitumor nature, as well as immunosuppressants, antihypercholesterolemics, etc. Streptomycetes are crucial in the soil environment because their diverse metabolism allows them to degrade the insoluble remains of other organisms, including recalcitrant compounds such as lignocelluloses and chitin. Streptomycetes produce both substrate and aerial mycelium. The latter shows characteristic modes of branching, and in the course of the streptomycete complex life cycle, these hyphae are partly transformed into chains of spores, which are often called conidia or arthrospores. An important feature in Streptomyces is the presence of type-I peptidoglycan in the cell walls that contains characteristic interpeptide glycine bridges. Another remarkable trait of streptomycetes is that they contain very large (~8 million base pairs which is about twice the size of most bacterial genomes) linear chromosomes with distinct telomeres. These rearrangements consist of the deletion of several hundred kilobases, often associated with the amplification of an adjacent sequence, and lead to metabolic diversity within the Streptomyces group. Sequencing of several strains of Streptomyces is aimed partly on understanding the mechanisms involved in these diversification processes. This organism is a well known producer of the anti-parasitic agent avermectin which is widely used to rid livestock of worm and insect infestations and to protect large numbers of people from river blindness in sub-Saharan Africa.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
209423210250828hypothetical proteinBLASTP
2102402117331494ATPGTP-binding proteinQuickGO ontologyBLASTP
211730212659930integral membrane proteinQuickGO ontologyBLASTP
212678213562885integral membrane proteinQuickGO ontologyBLASTP
213608213823216hypothetical protein
213820214248429hypothetical proteinBLASTP
214245214706462hypothetical proteinBLASTP
214706215158453hypothetical proteinBLASTP
2151582186253468hypothetical proteinBLASTP
2189032207321830hypothetical proteinBLASTP
220848221402555acetyltransferaseQuickGO ontologyBLASTP
2213992228351437hypothetical proteinBLASTP
2228712246911821hypothetical proteinBLASTP
225238226227990hypothetical proteinBLASTP
2263122278201509amino acidmetabolite permeaseQuickGO ontologyBLASTP
227817228737921glutamine synthetaseQuickGO ontologyBLASTP
2298252369377113large secreted proteinQuickGO ontologyBLASTP
237437237682246hypothetical proteinBLASTP
237840238601762hypothetical proteinBLASTP
239037239462426hypothetical proteinBLASTP
239788240234447hypothetical proteinBLASTP
240325240903579TetR-family transcriptional regulatorQuickGO ontologyBLASTP
241742241966225Tn4561 family transposaseQuickGO ontologyBLASTP
241989242195207transposaseQuickGO ontologyBLASTP
242908243411504IstB-like ATP-binding proteinQuickGO ontologyBLASTP
2435812447711191IS110 family transposaseQuickGO ontologyBLASTP
245081246040960regulatory proteinQuickGO ontology
246027246653627hypothetical protein
247471248142672hypothetical protein
248139248741603RNA polymerase ECF-subfamily sigma factorQuickGO ontology
249173249661489hypothetical protein
2497332534163684hypothetical proteinBLASTP
254011254895885pyrophosphataseQuickGO ontologyBLASTP
255013255273261acyl carrier proteinQuickGO ontology
255270255677408transcriptional regulatorQuickGO ontologyBLASTP
255674256570897hypothetical proteinBLASTP
256598257401804hypothetical proteinBLASTP
2574432584741032hypothetical proteinBLASTP
258522258809288hypothetical protein
2600242610791056DNA-binding proteinQuickGO ontologyBLASTP
2611392621911053hypothetical proteinBLASTP