Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:741169 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
741169742062894AraC-family regulatory proteinQuickGO ontologyBLASTP
742154742816663putative DedA-family membrane proteinQuickGO ontologyBLASTP
7430097442201212cystathionine beta-lyaseQuickGO ontologyBLASTP
745023745736714MotATolQExbB proton channel family proteinQuickGO ontologyBLASTP
745740746171432ExbDTolR-family transport proteinQuickGO ontologyBLASTP
7462687478241557hypothetical proteinBLASTP
747849748355507hypothetical proteinBLASTP
748405748875471hypothetical proteinBLASTP
748875749609735hypothetical proteinBLASTP
749629750462834hypothetical proteinBLASTP
750459751334876hypothetical proteinBLASTP
7513317526171287putative type II secretion proteinQuickGO ontologyBLASTP
7526297538611233hypothetical proteinBLASTP
755369756235867hypothetical proteinBLASTP
756287756709423hypothetical proteinBLASTP
756909757367459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
757619758077459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
7584307609102481outer membrane usher proteinQuickGO ontologyBLASTP
760928761647720fimbrial chaperone proteinQuickGO ontologyBLASTP
7616727627781107Fimbrial proteinQuickGO ontologyBLASTP
7629907640031014periplasmic binding proteinQuickGO ontologyBLASTP
764925765920996hypothetical proteinBLASTP
766012766581570putative lipoproteinQuickGO ontologyBLASTP
7688777700101134flagellar biosynthesis proteinQuickGO ontologyBLASTP
770010770783774putative flagellar assembly proteinQuickGO ontologyBLASTP