Pre_GI Gene

Some Help

Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:675622 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
675622676104483hypothetical proteinBLASTP
6761556783382184putative glycosyl hydrolaseQuickGO ontologyBLASTP
6784026799281527hypothetical proteinBLASTP
6799336817021770hypothetical proteinBLASTP
6818186828671050putative HlyD family secretion proteinQuickGO ontologyBLASTP
682877683203327hypothetical proteinBLASTP
683209683409201hypothetical proteinBLASTP
683582683689108hypothetical proteinBLASTP
6841756854071233putative aminotransferaseQuickGO ontologyBLASTP
6854006868511452hypothetical proteinBLASTP
686855687301447hypothetical proteinBLASTP
687471688061591hypothetical proteinBLASTP
688077688457381putative translational inhibitor proteinQuickGO ontologyBLASTP
688742689146405putative translational inhibitor proteinQuickGO ontologyBLASTP
689361689663303hypothetical proteinBLASTP
689923690639717hypothetical proteinBLASTP
690801691733933LysR-family regulatory proteinQuickGO ontologyBLASTP
692692692850159hypothetical proteinBLASTP
693048693248201hypothetical proteinBLASTP
693382693636255hypothetical proteinBLASTP
6938016948231023transposase for insertion sequence IS100QuickGO ontologyBLASTP
694820695602783transposaseIS proteinQuickGO ontologyBLASTP
6957286971101383hypothetical proteinBLASTP
697119697589471hypothetical proteinBLASTP
697667698071405hypothetical proteinBLASTP
698088698378291hypothetical proteinBLASTP