Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:524755 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
5237765247719964-hydroxythreonine-4-phosphate dehydrogenaseQuickGO ontologyBLASTP
5247555260591305survival protein SurA precursor peptidyl-prolyl cis-trans isomeraseQuickGO ontologyBLASTP
5261275284692343organic solvent tolerance protein precursorQuickGO ontologyBLASTP
528654529487834Dna-J like membrane chaperone proteinQuickGO ontologyBLASTP
529785530405621ribosomal large subunit pseudouridine synthase AQuickGO ontologyBLASTP
531628532371744hypothetical proteinBLASTP
5327015337141014hypothetical proteinBLASTP
533725534285561hypothetical proteinBLASTP
5342855357961512hypothetical proteinBLASTP
535959536477519hypothetical proteinBLASTP
536551536994444hypothetical proteinBLASTP
5370275388711845hypothetical proteinBLASTP
538864539847984hypothetical proteinBLASTP
5398505424532604putative Clp ATPaseQuickGO ontologyBLASTP
5425575449052349hypothetical proteinBLASTP
544918545490573hypothetical proteinBLASTP
5455155471371623hypothetical proteinBLASTP