Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:483395 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

This island contains ribosomal proteins or RNA related elements and may indicate a False Positive Prediction!

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
4833954858542460bifunctional aspartokinase Ihomeserine dehydrogenase IQuickGO ontologyBLASTP
485857486786930homoserine kinaseQuickGO ontologyBLASTP
4867904880791290threonine synthaseQuickGO ontologyBLASTP
488896489672777hypothetical proteinBLASTP
490204491157954transaldolaseQuickGO ontologyBLASTP
491445492032588molybdenum cofactor biosynthesis proteinQuickGO ontologyBLASTP
4921604935481389putative transport proteinQuickGO ontologyBLASTP
4936184960652448hypothetical proteinBLASTP
496354496965612hypothetical proteinBLASTP
4973394992491911molecular chaperone DnaKQuickGO ontologyBLASTP
4993615005001140chaperone protein DnaJQuickGO ontologyBLASTP
5007435019271185sodium-proton antiporterQuickGO ontologyBLASTP
502057502956900transcriptional activator protein NhaRQuickGO ontologyBLASTP
50308750335026430S ribosomal protein S20QuickGO ontologyBLASTP