Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:4105754 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
410575441102444491insecticidal toxin complexQuickGO ontologyBLASTP
411393441164352502putative insecticial toxinQuickGO ontologyBLASTP
41166714117537867putative lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
41177984118709912probable lysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
41190124119215204hypothetical proteinBLASTP
41192234120158936putative HlyD family secretion proteinQuickGO ontologyBLASTP
412016041221151956hypothetical proteinBLASTP
41240604124518459putative ribonucleaseQuickGO ontologyBLASTP
41245234124804282putative ribonuclease inhibitorQuickGO ontologyBLASTP
41249164125464549hypothetical proteinBLASTP
412564541269851341Putative modulator of DNA gyraseQuickGO ontologyBLASTP
41272404127878639hypothetical proteinBLASTP
41280864128472387putative cytochromeQuickGO ontologyBLASTP
41286964129106411nucleoside diphosphate kinase regulatorQuickGO ontologyBLASTP