Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:4006884 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
400688440094872604Clp ATPaseQuickGO ontologyBLASTP
40094844010281798hypothetical proteinBLASTP
40102784010964687hypothetical proteinBLASTP
401096140123581398hypothetical proteinBLASTP
401239040159233534hypothetical proteinBLASTP
40160484016830783hypothetical proteinBLASTP
40168274017360534hypothetical proteinBLASTP
401738240197842403putative Rhs accessory genetic elementQuickGO ontologyBLASTP
40197904020248459hypothetical proteinBLASTP
402024140231052865hypothetical proteinBLASTP
402313340245031371hypothetical proteinBLASTP
40245054024990486hypothetical proteinBLASTP
40250404025231192hypothetical proteinBLASTP
40256134026020408putative transcriptional regulatory proteinQuickGO ontologyBLASTP
402638140285792199putative Rhs accessory genetic elementQuickGO ontologyBLASTP