Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:398748 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
3987484003911644putative acyl-CoA dehydrogenaseQuickGO ontologyBLASTP
400463400774312putative lipoproteinQuickGO ontologyBLASTP
401114401896783transposaseIS proteinQuickGO ontologyBLASTP
4018934029151023transposase for insertion sequence IS100QuickGO ontologyBLASTP
4030494051122064hypothetical proteinBLASTP
4051094064251317hypothetical proteinBLASTP
406492406722231hypothetical proteinBLASTP
406969407436468hypothetical proteinBLASTP
4074494087741326modification methylaseQuickGO ontologyBLASTP
408824409546723hypothetical proteinBLASTP
4096564108911236hypothetical proteinBLASTP
411235411522288hypothetical proteinBLASTP
41196241205493transposase partialQuickGO ontologyBLASTP
4121394135511413hypothetical proteinBLASTP
4135484147021155hypothetical proteinBLASTP
4148484158941047M48 peptidase family proteinQuickGO ontologyBLASTP
4159054171011197hypothetical proteinBLASTP
417807418343537hypothetical proteinBLASTP
418345419220876putative transcriptional regulatorQuickGO ontologyBLASTP
419213419557345PTS system IIB componentQuickGO ontologyBLASTP
419650419970321PTS system IIB componentQuickGO ontologyBLASTP
4203114213961086PTS system IIC componentQuickGO ontologyBLASTP
4217584243162559putative phosphoenolpyruvate-protein phosphotransferaseQuickGO ontologyBLASTP