Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:3583468 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
35834683584226759hypothetical proteinBLASTP
358455435858131260gamma-glutamyl phosphate reductaseQuickGO ontologyBLASTP
358582335869261104gamma-glutamyl kinaseQuickGO ontologyBLASTP
35871033587504402curlin genes regulatory proteinQuickGO ontologyBLASTP
358756435888111248hypothetical proteinBLASTP
35889383589396459xanthine phosphoribosyltransferaseQuickGO ontologyBLASTP
35898233590128306hypothetical proteinBLASTP
359032535919291605putative carbohydrate-binding proteinQuickGO ontologyBLASTP
35923893593300912putative LysR-family transcriptional regulatory proteinQuickGO ontologyBLASTP
35940223594177156hypothetical proteinBLASTP
359517535966351461aminoacyl-histidine dipeptidaseQuickGO ontologyBLASTP
359674935978071059DNA polymerase IVQuickGO ontologyBLASTP
35981633599110948hypothetical proteinBLASTP
35993543599581228hypothetical proteinBLASTP
359959436006161023thiamine biosynthesis lipoproteinQuickGO ontologyBLASTP
360065736018801224Na-translocating NADH-quinone reductase subunit FQuickGO ontologyBLASTP
36018963602492597Na-translocating NADH-quinone reductase subunit EQuickGO ontologyBLASTP
36024993603128630NADH-ubiquinone oxidoreductaseQuickGO ontologyBLASTP
36031213603921801Na-translocating NADH-quinone reductase subunit CQuickGO ontologyBLASTP
360391136051521242Na-translocating NADH-quinone reductase subunit BQuickGO ontologyBLASTP