Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:3446740 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
34467403447024285hypothetical proteinBLASTP
344906534502791215putative membrane efflux proteinQuickGO ontologyBLASTP
345051434522051692putative potassium antiporterQuickGO ontologyBLASTP
345230234536061305inosine-guanosine kinaseQuickGO ontologyBLASTP
345381034549611152O-antigen chain length determinantQuickGO ontologyBLASTP
345500934563821374phosphomannomutaseQuickGO ontologyBLASTP
34563873457130744probable glycosyltransferaseQuickGO ontologyBLASTP
345713334585451413mannose-1-phosphate guanylyltransferaseQuickGO ontologyBLASTP
346084134618541014putative mannosyltransferaseQuickGO ontologyBLASTP
346332134644631143putative mannosyltransferaseQuickGO ontologyBLASTP