Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:3346834 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
334683433481831350putative two-component system sensor kinaseQuickGO ontologyBLASTP
33482093348892684putative two-component system response regulatorQuickGO ontologyBLASTP
334908033502851206putative HlyD family secretion proteinQuickGO ontologyBLASTP
335028933523252037putative ABC transporter ATP-binding proteinQuickGO ontologyBLASTP
335258033542261647putative pyridine nucleotide-disulphide oxidoreductaseQuickGO ontologyBLASTP
335428633557461461putative permeaseQuickGO ontologyBLASTP
33557433355940198hypothetical proteinBLASTP
335733633585171182putative aminotransferaseQuickGO ontologyBLASTP
335911433606431530hypothetical proteinBLASTP
336087633624201545putative two-component sensor histidine kinaseQuickGO ontologyBLASTP
33624173363124708putative two-component response regulatorQuickGO ontologyBLASTP
336350533647371233hypothetical proteinBLASTP
33649823365860879cysteine synthase BQuickGO ontologyBLASTP
336603133671221092sulfate transport ATP-binding proteinQuickGO ontologyBLASTP
33671123367987876sulfate transport system permease protein CysWQuickGO ontologyBLASTP
33679873368820834sulfate transport system permease protein CysTQuickGO ontologyBLASTP
336882033698571038thiosulfate-binding proteinQuickGO ontologyBLASTP