Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:3191246 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
319124631926401395putative proteaseQuickGO ontologyBLASTP
31932763194166891putative diacylglycerol kinaseQuickGO ontologyBLASTP
31944333194897465hypothetical proteinBLASTP
31952913196061771hypothetical proteinBLASTP
31961233196923801phosphomethylpyrimidine kinaseQuickGO ontologyBLASTP
31974333197912480hypothetical proteinBLASTP
319826131994691209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
31995513200195645hypothetical proteinBLASTP
32001923200587396hypothetical proteinBLASTP
32006513201046396hypothetical proteinBLASTP
32010843201503420hypothetical proteinBLASTP
32015673201965399hypothetical proteinBLASTP
32019893202468480hypothetical proteinBLASTP
32026283203086459transposase for the IS1541 insertion elementQuickGO ontologyBLASTP
320346132050381578bifunctional GMP synthaseglutamine amidotransferase proteinQuickGO ontologyBLASTP
320521832066811464inositol-5-monophosphate dehydrogenaseQuickGO ontologyBLASTP
320685132082301380exodeoxyribonuclease VII large subunitQuickGO ontologyBLASTP
32083633208587225hypothetical proteinBLASTP
32086363209592957hypothetical proteinBLASTP
320993932114261488GTP-binding protein EngAQuickGO ontologyBLASTP
321157432127551182putative lipoproteinQuickGO ontologyBLASTP