Pre_GI Gene

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Host: NC_003143 NEIGHBOURS BLASTN Download Island sequence Download Island gene sequence(s)

NC_003143:3115933 Yersinia pestis CO92, complete genome

Host Lineage: Yersinia pestis; Yersinia; Enterobacteriaceae; Enterobacteriales; Proteobacteria; Bacteria

General Information: This strain is a recent Orientalis subtype isolated in the USA from a patient who died of pneumonic plague after acquiring the disease from an infected cat. Causative agent of plague. Specific virulence factors are encoded within pathogenicity islands (PAIs) that are required for the invasive phenotype associated with Yersinia infections. One key virulence plasmid contained by the three human-specific pathogens is pCD1/pYv, which encodes a type III secretion system for the delivery of virulence proteins that contribute to internalization into the host cell. It is the causative agent of plague (bubonic and pulmonary) a devastating disease which has killed millions worldwide. The organism can be transmitted from rats to humans through the bite of an infected flea or from human-to-human through the air during widespread infection. Yersinia pestis is an extremely pathogenic organism that requires very few numbers in order to cause disease, and is often lethal if left untreated. The organism is enteroinvasive, and can survive and propagate in macrophages prior to spreading systemically throughout the host. Yersinia pestis consists of three biotypes or serovars, Antiqua, Mediavalis, and Orientalis, that are associated with three major pandemics throughout human history. pMT1 encodes a protein, murine toxin, that aids rat-to-human transmission by enhancing survival of the organism in the flea midgut. Yersinia pestis also contains a PAI on the chromosome that is similar to the SPI-2 PAI from Salmonella that allows intracellular survival in the organism.

StartEndLengthCDS descriptionQuickGO ontologyBLASTP
311593331171891257ascorbate-specific PTS system enzyme IICQuickGO ontologyBLASTP
311732931185371209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
31203163120561246putative DNA-binding proteinQuickGO ontologyBLASTP
31212343121815582hypothetical proteinBLASTP
31220833122484402hypothetical proteinBLASTP
31227383123118381hypothetical proteinBLASTP
31231303123702573hypothetical proteinBLASTP
31237263123977252hypothetical proteinBLASTP
31240163124255240hypothetical proteinBLASTP
312506431269801917putaive autotransporter proteinQuickGO ontologyBLASTP
31275153128096582hypothetical proteinBLASTP
31281113128461351conserved hypothetical protein partialQuickGO ontologyBLASTP
312849831297061209transposase for the IS285 insertion elementQuickGO ontologyBLASTP
313015831323652208hypothetical proteinBLASTP
31323583132888531hypothetical proteinBLASTP
313304731354282382putative beta-glucosidaseQuickGO ontologyBLASTP
313550731371351629hypothetical proteinBLASTP
31375663138459894putative aldoketo reductaseQuickGO ontologyBLASTP